PCAsso is developing PolyChromatic Angiography (PCA), the next generation angiography. PCA is a novel imaging technology that will provide quantitative information on the blood-rtinal barrier (BRB) dysfunction, a pathological mechanism that leads to vision loss in many retinal diseases including diabetic retinopathy, neovascular age-related macular degeneration and uveitis.

PCA Concept

PCA uses multiple fluorophores simultaneously to quantitatively assess BRB dysfunction. Each fluorophore (dye) is loaded on a biocompatible and biodegradable particle of specific size range (Upper figure).

In cases of mild BRB dysfunction, only the fluorophores bound to the smallest nanoparticles leak. In cases of more severe BRB dysfunction, fluorophores bound to larger particles also leak. The detected leaking fluorophores indicate the grade of BRB dysfunction (Lower Figure).

Grading BRB dysfunction provides ophthalmologists with the next level of diagnostic granularity.   The granular information provided by PCA will help ophthalmologists better grade the disease severity and tailor treatment accordingly, thus preventing both under-treatment and over-treatment.